CXCL8 – The First Chemokine

CXCL8 – The First Chemokine

After spending 2 years at the Rockefeller University in New York, as a research associate in the laboratory of Christian de Duve, I accepted an offer from Sandoz Ltd., which was attractive in terms of space, equipment, and research facilities, and returned to Switzerland. Beatrice Dewald, joined my laboratory after several years at NYU and Vanderbilt University, and we continued our studies of ...

The Chemokine CXCL8 in Carcinogenesis and Drug Response

Although the functions of chemokines in the regulation of immune processes have been studied in some detail, the role of these biomolecules in cancer is not fully understood. Chemokines mediate migration of immune cells and other functions related to immunity. They are also involved in oncogenesis and in tumor progression, invasion, and metastasis through mechanisms similar to their roles in im...

Chemokine CXCL8 Mediated Intercellular Interactions in HIV-1 associated Dementia

This dissertation explores the role of chemokine CXCL8 during human immune deficiency virus (HIV)-1 infection in the brain. Chemokine CXCL8 is an important neutrophil chemoattractant implicated in various neurodegenerative disorders. It is upregulated in the brains and cerebrospinal fluid of HIV-1 infected individuals suggesting its potential role in HIV-1 associated neuroinflammation. Astrocyt...

Protein Binds to the N Terminus of CXCL8 The Gammaherpesvirus Chemokine Binding

The gammaherpesvirus chemokine binding protein binds to the N terminus of CXCL8.

Viruses encode proteins that disrupt chemokine responses. The murine gammaherpesvirus 68 gene M3 encodes a chemokine binding protein (vCKBP-3) which has no sequence similarity to chemokine receptors but inhibits chemokine receptor binding and activity. We have used a panel of CXCL8 analogs to identify the structural requirements for CXCL8 to bind to vCKBP-3 in a scintillation proximity assay. O...